Endocrine Abstracts

Background: Minimally invasive parathyroidectomy (MIP) for primary hyperparathyroidism is routinely performed in many centres. Various preoperative and intraoperative localisation techniques are used along with intraoperative PTH monitoring (IOPTH).Results: We report the results of 110 consecutive patients presenting to our unit with a diagnosis of primary hyperparathyroidism from January 2004 until November 2007. All patients had sestamibi scintigraphy ...

Background and Importance: Precocious puberty refers to sexual characteristics development before the normal age for its development. Neurofibromatosis Type 1 is an autosomal dominant condition with wide spectrum of clinical phenotype of which precocious puberty is common. This case report highlights the importance of recognizing this disease in patient presenting with precocious puberty and screening for optic pathway gliomas should be done and treat it to prevent the future ...

Introduction: Waterhouse Friedrichsen syndrome-Severe adrenal insufficiency is a rare but life-threatening condition secondary to bilateral adrenal haemorrhages. In many cases, it is caused by fulminant meningococcaemia, but there are numerous other aetiologies, it can also be caused by use of medications that promote blood clotting, reduce platelet count, primary antiphospholipid syndrome, renal vein thrombosis or steroid use and has been associated with splenectomy as well. ...

A 54 years old female with no significant past medical history was referred by her GP with thyrotoxic symptoms which were not improving on Carbimazole 40 mg daily over the last 3 months in spite of good compliance with the drug. Her initial FT4 was 49.0 pmol/l with TSH suppressed to <0.01 and she was started on Carbimazole 20 mg which a month later was increased to 40 mg/day when there was no improvement in her TFTs. Her TFTs at this point showed FT4 ...

Introduction: A biochemical profile of an underactive pituitary gland allied to visual field loss is commonly due to an underlying adenoma. We report a case where such a clinical picture was found but imaging/biopsy revealed a different cause.Case report: A 52-year-old Indian male was referred by his GP to an endocrine outpatient department with reduced visual acuity, balance problems and a biochemical profile of an underactive pituitary gland. Past hist...

Background: The PCSK9 inhibitors (PCSKi), evolocumab and alirocumab, were approved by NICE in 2016, and have since proved to be efficacious in lowering LDL-C. Yet little is known about their long-term adverse effects. Genetic studies have shown patients with PCSK9 loss-of-function variants are at increased risk of T2DM. Similarly, analyses of an adverse event database found increased reports of PCSK9i-related hyperglycaemia. Meta-analyses have suggested that P...

Teddy is a highly proliferative goat breed, as females of this breed are famous for high twinning rates. Feed supplementation of olive oil has been shown to improve semen quality of goat bucks. In this study, the effects of feed supplementation with olive oil on serum testosterone, triiodothyronine (T3), thyroxine (T4) and some biochemical metabolites in Teddy goat bucks were investigated. For this purpose, 9 adult male goats, with clinically normal reproduc...

Teddy is a highly proliferative goat breed, as females of this breed are famous for high twinning rates. Feed supplementation of olive oil has been shown to improve semen quality of goat bucks. In this study, the effects of feed supplementation with olive oil on serum testosterone, triiodothyronine (T3), thyroxine (T4) and some biochemical metabolites in Teddy goat bucks were investigated. For this purpose, 9 adult male goats, with clinically normal reproduc...

Introduction: We describe the case of a patient referred to Cardiology with an abnormal ECG & hypertension. Investigation led to the diagnosis of catecholamine induced cardiomyopathy caused by a pheochromocytoma. The case is unique as the cardiomyopathy was reversed with alpha and beta blockade prior to surgery.Case: A 56 year old female with 20 pack year smoking history, no regular medications and evidence of hypertension underwent CT AP for abdomin...

: We present a case of 79 year old lady who presented to hospital with symptoms of polyuria and polydipsia requiring admission for level 3 care. She reported no bowel symptoms or alcohol usage. Her past medical history showed that she suffered from T2DM, Epilepsy, Asthma, Hypertension and Chronic Kidney disease. Her biochemistry revealed a combination of Hyperglycaemia, Hypokalaemia, Hypomagnesemia, Hypophosphatemia, Hyponatremia and Hypocalcaemia. Her medications revealed no ...